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ET-KING – Enkai Kashu ET-KINGが活動再開をアナウンス。メンバー7人での未発表曲を含むアルバム「宴会歌集」を9月16日にリリースすること、新生ET-KINGとしてニューシングル「喝采」を10月21日にリリースすること、さらに本日7月1日（水）にFM OSAKA「LOVE FLAP」に生出演することを一斉に発表した。 2014年4月に大阪・フェスティバルホールで行われた全国ツアーファイナルをもって”充電期間”に入ったET-KING。その後それぞれがソロ活動を行う中、同年9月にメンバーTENNの急死という出来事があり、それを受け止められない時期もあったという。しかしこのたび、3年がかりでメンバー全員で作り上げたスタジオが完成し、新たな仲間とともにプロダクションを立ち上げ、6人で再始動する運びとなった。 「宴会歌集」は、ET-KINGのテーマ別アルバム「歌集シリーズ」のラストを飾る第4弾。過去に録音したすべての未発表曲と”宴会ソング”の名にふさわしい既存曲を集めたアルバムとなる。4曲の未発表曲と2曲の未CD化楽曲には、TENNの歌唱もすべて収録される。楽しいことやにぎやかな場所が大好きだったTENNの遺志も汲んだ、ET-KINGらしい盛り上がれる12曲が堪能できる。なお未発表曲の1つ「Splash！」は本日7月1日から先行配信およびMV公開が行われている。 1. 纒 ~花の慶次バージョン~ 10. わっしょい二次会 DOWNLOAD / ダウンロード / 下载 Uploaded.net (ul.to) Uploadable.ch Faststore.org.

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Abstract Endogenous retinoids like all- trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases. The present study used topical application of selective agonists and antagonists for retinoic acid receptors (RARs) α and γ and retinoid-X receptors (RXRs) for two weeks on mouse skin in order to determine the role of retinoid receptor subtypes in the gene regulation in skin. We observed pronounced epidermal hyperproliferation upon application of ATRA and synthetic agonists for RARγ and RXR. ATRA and the RARγ agonist further increased retinoid target gene expression (Rbp1, Crabp2, Krt4, Cyp26a1, Cyp26b1) and the chemokines Ccl17 and Ccl22.

In contrast, a RARα agonist strongly decreased the expression of ATRA-synthesis enzymes, of retinoid target genes, markers of skin homeostasis, and various cytokines in the skin, thereby markedly resembling the expression profile induced by RXR and RAR antagonists. Our results indicate that RARα and RARγ subtypes possess different roles in the skin and may be of relevance for the auto-regulation of endogenous retinoid signaling in skin. We suggest that dysregulated retinoid signaling in the skin mediated by RXR, RARα and/or RARγ may promote skin-based inflammation and dysregulation of skin barrier properties. Introduction The nuclear hormone receptors retinoic acid receptors (RAR) α, β, and γ and retinoid X receptors (RXR) α, β, and γ are ligand-dependent transcription factors that can be activated by retinoids. RAR-RXR heterodimers regulate the expression of multiple genes in skin and various other tissues, while their transcriptional activity is dependent on the RAR-activating ligand –. The most abundant RAR and RXR subtypes in skin are RXRα and RARγ, followed by lower quantities of RARα. Since retinoid receptors exhibit tissue and cell type-specific distribution patterns, functional specificity of each subtype is suggested –.

Moreover, RAR and RXR subtypes differ in ligand specificity and/or affinity, –, therefore, it can be assumed that their contribution to gene expression patterns in skin differs, depending on quantitative receptor distribution, on the nature and level of co-regulators, as well as on available retinoid receptor-selective agonists and antagonists. RAR-RXR-mediated signaling pathways induced by retinoids are essentially involved in immune-modulatory events –, and skin physiology through their role in the regulation of several aspects of skin cell proliferation, differentiation, apoptosis, and epidermal barrier function,. Retinoid metabolism and concentrations in skin are tightly regulated ensuring sufficient levels of the endogenous pan-RAR activator all- trans retinoic acid (ATRA),,. However, alterations in retinoid metabolism, signaling and concentrations have been observed in various dermatoses, such as psoriasis, ichthyosis, and recently in a study by our group in atopic dermatitis. Altered retinoid-mediated signaling in skin of these patients may also be a result of activation or antagonism of specific retinoid receptor subtypes under disease conditions.

In order to dissect retinoid-mediated signaling in skin, mice were treated topically for two weeks with selective RAR and RXR agonists or antagonists. Our aim was to determine the effect of RAR subtype-selective and RXR activation or antagonism on the expression of genes involved in retinoid metabolism and signaling, as well as epidermal barrier homeostasis and skin-based immune regulation. The outcome of the present study will help to identify pathways and genes that are selectively regulated by RARα, RARγ, or RXR in the skin of mice. This might allow for conclusions regarding the involvement of subtype-specific retinoid receptor-mediated signaling in various skin diseases and may suggest alternative therapeutic strategies.